I quit using skimmers in '97 and haven't regretted it. Here's links to some of my skimmerless tanks:
23 yeqr old system
http://youtu.be/KhcRz50cV0s
500 system
http://youtu.be/_Uf5IyXvajg
240 filterless system
http://youtu.be/-eCQSVdqBQA
17 year old system
http://youtu.be/5AnmQXmE8d0
Sump of 17 year old system
http://youtu.be/WDj0daKV2B8
Green Slimer Timeline
https://www.youtube.com/watch?v=DyM6Y39iQ8M
Feldman, et al, did an intersting series of articles looking at GAC, skimmers and TOC (Total Organic Carbon). (I skip over a lot of the description of how the experiments were set up.)
Granular Activated Carbon Pt 1
http://www.advancedaquarist.com/2008/1/aafeature1
Granular Activated Carbon Pt 2
http://www.advancedaquarist.com/2008/2/aafeature1
Total Organic Carbon Pt 1
http://www.advancedaquarist.com/2008/8/aafeature3
Total Organic Carbon Pt 2
http://www.advancedaquarist.com/2008/9/aafeature2
Protein Skimmer Performance, Pt 1
http://www.advancedaquarist.com/2009/1/aafeature2
Protein Skimmer Performance, Pt 2
http://www.advancedaquarist.com/2010/1/aafeature
Skimmate Analysis
http://www.advancedaquarist.com/2010/2/aafeature
Bacterial Counts in Reef Aquarium Water
http://www.advancedaquarist.com/2011/3/aafeature
Feldman's research showing skimmers are not good at removing TOC, also called DOM (Dissolved Organic Matter) got me looking into TOC closer. Unfortunately we as hobbiest cannot test for it but TOC can be divided into POC (Particulate Organic Carbon), about 10%, and DOC (Dissolved Organic Carbon), about 90%. The DOC can be crudely divided into Labile or easily consumed by microbes; Semi-Labile, less easily consumed by microbes and Refractory or very resistant to being broken down or removed. The refractory portion of DOC is roughly 2/3rds the total of DOC. Some of the papers I've found include:
DOC released by corals promotes autotrophic (good) microbes, DOC released by algae promotes heterotrophic (bad) microbes. (We need to think of corals in our systems as autotrophs)
http://www.ncbi.nlm.nih.gov/pubmed/23303369
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719129/
DOC released by algae kills corals, not phosphate or nitrogen
http://www.int-res.com/articles/meps2006/314/m314p119.pdf
http://www.ncbi.nlm.nih.gov/pubmed/16796574
Sponges "eat" DOC and convert it into DIC (alklainity)
https://www.researchgate.net/publication/279061640_2013_deGoeij_Science_Sponge_loop
http://www.rug.nl/research/portal/files/14555035/13completethesis.pdf
My own experience over the decades has been small frequent water changes are what's essential to keeping reef aquariums for decades, not skimmers. Now with the science now showing skimmers do not remove a significant portion of DOC, skimmers are likely removing only the labile types of DOC which includes the good types released by corals that promote autotrophic microbes and is food for sponges, and skimmers do alter the microbial populations in systems compared to pristine reefs I'll argue they may be irrelevant or even detrimental to the long term success (as in decades and decades) of reef systems.