It is okay if you use your bare hands as long as you don't have any open sores or cuts. Just be sure to wash your hands realy good and don't touch your eyes, mouth or nose when you have zoa "juice" on them. That is what can make you sick.
I advise gloves and goggles/glasses when working/fragging them. The can squirt.
zoaid.com has a fragging article on this with step by step and photos too. It is very good. If it hadn't been for this, I may not have felt comfortable/if I even did it at all fragging zoas.
Check it out!