it's as much work as you make it.
i just upgraded from a 75 to a 160, and my work has actually decreased. with the larger tank i was able to plumb supply and drain lines up through the floor, and setup a large saltwater mixing station in the basement.
that cut the amount of work i have to do drastically, and no more bucket brigade!
testing is the same, feeding is the same, conceptually not much else has changed.
i'm going to be dosing more, and need to mix larger batches of water for my water changes, but with the changes i've made in the logistics, this won't surpass the offset of time savings from the new setup.