I'm helping to put a 110 together for a friend and just put two of the 3s in it. I really think they do good on the 4' tank, but suggested that if he gets the SPS bug down the road to add another 3 or mayby a 2 in there.
I'm running two 4s in my 125 and it does pretty well on a wavemaker(agaisnt recomendations, but they are timed for two hours per side with a 1/2 hour overlap).