Man O' War Fish?

I would argue that pituitary adenomas in children, a cause of giantism, is from a somatic mutation in tumor suppressor, promotor or some other regulatory gene.

You could argue that, and it is certainly possible (via naturally-occurring DNA damage/ replication errors), but not all hyperplasia conditions are cancerous, with cancerous growths often termed neoplasia - the use of the term "hyperplasia" usually excludes tumors, although it may denote premalignant conditions...
 
Not to be "that guy", but Mr. Wadlow's extreme condition was not the result of "mutation" (his genome did not change), but rather hyperplasia (excess cellular growth) of the pituitary gland, which resulted in excess production of human growth hormone...

Yep, it's not a mutation but rather a hormone imbalance caused by a gland disease.

Mutations are (abnormal) changes on DNA/RNA level that can be passed on to offspring.

As for the fish's size: 15 inches / 40 cm isn't spectacular or even unusual. Most of the large angel fish like P. imperator get that big (unless you stun their growth by keeping them in a too small tank).

Also if keeping it without it's host is of concern I would rather lament the unnatural keeping of many clownfish without anemone or suitable surrogate.
 
Is it possible to keep a man o' war jellyfish in captivity?

It's actually not a jellyfish. It's a siphonophore, not a single organism, but many. And extremely venomous. I would say it's not possible to be kept in captivity.
 
When I used to run a LFS, the local diver here used to bring them in every once in a while. they hid all the time and eventually just starved no matter what we tried to bring them out. They are one that are better left in the wild IMO
 
Is it possible to keep a man o' war jellyfish in captivity?

Looks like the answer to that question is "not yet"

"Aquarium design for the Portuguese man-of-war Physalia phy salis
Maintaining the Portuguese man-of-war Physalia physalis in captivity, either for display or study, has not been successful to date. A new aquarium was designed and constructed in an attempt to simulate natural conditions so more could be learned about the husbandry requirements of this species. The prototype aquarium increased longevity, up to four to seven times that of previous attempts, and promoted natural behaviours. Inside the aquarium six acrylic containment cylinders, each containing one Portuguese man-of-war, held the animals away from the sides and the force of water being drawn down through the cylinders retained the centred position of the specimens. Detailed information is given on the design of the aquarium in relation to the natural behaviour of the Portuguese man-of-war.
"
Source: http://onlinelibrary.wiley.com/doi/10.1111/j.1748-1090.2006.00221.x/abstract
 
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