b0bab0ey, I have been messing around a bit with quinine and I havd seen some interesting things. First off I completed the first week of the recommended 2 week treatments with a 25% water change on day 7. Like I said, none of the fish experienced any new spot. So I decided to add a new untreated fish to the tank to see if I still had any viable ich in the tank. The first two days no new white spots. Then on day three the new fish developed spots. This did not surprise me at all. Would seem that the ich did not completely die off after only one 7 day treatment. But after 6 days with the treatment the new fish has no new spots. So I am going to get a few more fish and try to do a controled study with them to see if my 75 gal will be clean after the time of treatment. I am now wondering how long the fish carry the quinine in their systems.