Garlic has been studied for its effectiveness against a bacterial infection of fish (Colorni et al, 1998). One hundred and sixty sea bass (Dicentrarchus labrax) were intentionally infected with Mycobacterium marinum via injection with cultured cells. The study's participants also kept a positive control group of another 40 specimens, which they held in conditions similar to, but separate from, the infected fish, but injected them only with saline. All of these fish were then held and monitored to watch the disease's progression. After nine weeks, the infected fish showed clinical signs of infection upon dissection and examination. At this point, the infected fish were broken up into four smaller groups of 40 each: a negative control group which received no treatment, an experimental group that received antibiotic (streptomycin) injections, a second experimental group that received garlic extract injections, and a third experimental group that received injections of both the antibiotic and garlic extract. All fish were treated for an additional 12 weeks. During this time, sample fish were selected and dissected to monitor the disease's progression or recession.
The interesting revelation that came from this study is that it revealed a statistically significant stronger immune response in the fish given only garlic versus the fish given antibiotics, antibiotics and garlic, or the untreated control group. Part of this apparent anomaly is that antibiotics also have an immunosuppressive effect. In layman's terms, while they work to kill bacteria, they also don't permit the body to fight as hard as normal against the infection. But, the fact that the fish treated with garlic showed a stronger immune response than the untreated control group lead the study authors to suggest that "allicin treatment seems to have an enhancing effect on antibody activity when compared with all other groups."
