Either way works. I built one decades ago out of 2x's, then skinned with T&G bead board to match the kitchen it is in. Still there, still looks good, sister is still happy. A properly built plywood stand will hold the weight of a tank no problem. Lots of people don't have the skill or tools needed to work with large sheets. Go look at any factory stands at your LFS.. I have never seen one with a 2x substructure.. But I do see plenty made of MDF and such.. those scare me way more than ply.. because if they get wet... well we all know what happens then.. and we all know "wet" is going to happen. They are often reinforced in the corners with a second piece of MDF for strength, because they don't have long fibers in them to hold up the weight.
Now.. real story about "plywood and tank" (well almost a "tank") I have personally seen, and worked on a Bradley Fighting Vehicle that had its complete suspension system removed, and it was supported by only 4 plywood "boxes" about 2 foot square and cross braced in one direction. Those boxes weighed less than 40lbs each.
I have also worked on M60 series tanks that were in the same status, but sitting on 4 oak cubes, about 18" on a side. Now those blocks weighed about 175 pounds, but they were supporting around 50 TONS.
I am a carpenter and artist who works with wood.. so I have access to a great cabinet saw and lay up table.. my display stands I built are done with plywood and solid wood face frames. I build my own doors, but many people buy them built...
Current 70 in dining room, built to match the other furniture in there..
Underneath with lots of room.. (not a great pic.. but you can see how open it can be..)
And sometime.. 2x's ARE the right choice..
sump in basement..
I think the OP's point was that many stands are overbuilt for no reason.. he didn't maybe articulate it well though. I know I have seen stands on here built with 2x6's, then skinned in 3/4 ply.. I am sorry.. but I do get a chuckle out of those. The biggest stand I ever built is for a 380.. it's all plywood, been up about 8 years now, no problems.
The facts are that many feel comfortable with working with 2x's, and they do work. But 2x's are not as dimensionally stable as ply, by a long shot. All is good if it has an aquarium on it