I use cleaner, primer, and clear glue. Clear Oatleys is low VOC and I translate that into less toxic in general. However, it has a longer cure time than most alternatives. The joint is strong enough for the pressure of most reef systems far before I think it is safe to use on my tank. I wait 24 hrs and then soak in water and a little bleach to clean off any greases, oils, or pesticides that might have come with the pieces. Then RO/DI water and old carbon to remove any of the chlorine compounds remaining from the tap water and bleach. Then hang them up and let them dry. I you have the time why not make sure, although, if you don't I would wait until you cannot smell the glue. Clear glue is also more flexible and if you are a tinkerer like myself it is less likely to be compromised when you are working on the plumbing in the future.