I believe 2x's are the "best" choice for us average Joe non-professional builders as it provides extra insurance against novice beginner errors.
I disagree, if for no other reason than a novice has no idea how to deal with twist, bow, and crook, and probably doesn't even know what these things are. It is really hard to mess up butting two pieces of plywood together with some glue in between and spinning some screws in to act as clamps.
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This whole topic is so blown out of proportion, that it is almost silly. RE's design is a very solid design. I have a hard time finding anything that it won't hold up. However, that is not the whole story either.
I have read the 'tales' of manufactured stand failures, mostly anecdotal third party reports of some other stand that failed, (never their own.) Seldom have I seen any reports that contain a history of the stand (how much abuse did it suffer before it supposedly 'just failed,' cracked, fell apart; wavemakers are one source of such abuse) These stands are required by most tank manufacturers. Why? Because the top is dead flat, and they are strong enough to support the load. We would certainly be hearing of more lawsuits concerning failed stands, if they were truly the 'death traps' they are purported to be.
That being said, the pulse of the hobby is not entirely contained within forums and online informaton. This is a rather small segment of the hobby. There are literally thousands of manufactured stands, and diy lumber stands, and plywood box stands in use right now. A conclusion cannot really be drawn, simply because it has not been seen on the world wide web.
If we are to use the forums to take the 'temperature' of stand construction, the postings concerning manufactured stand failures are overshadowed, by orders of magnitude, by problems with DIY lumber stands, Why? The three things mentioned above, plus the tendency for dimensional changes in cut lumber, that can easily occur in the hour between cutting and assembly.
I had a manufactured standback in 84. It was well built using dimensioned lumber, bench jointed from 2 x 4, or perhaps 2 x 6. Dead flat, square and plumb. Nice wicker panels that matched the decor in the bar/pool room. After a while, the floor inside the stand started coming apart (water damage->read abuse) and after several moves, was getting a bit rickety (read->more abuse.) The tank ultimately failed, but it was a really easy task to undue the abuse to the stand and tighten it up. Angle bracket here, couple of screws and some glue both here and there. The stand never did fail, though it did end up in a dumpster after the tank failed. Oh, why...did the tank fail? Ahhh ummmm, acrylic tank on an open top stand? Having been in the hobby for so long, I have had a lot more time to do more stupid sh**, than most others....