Hey AR! Biggest thing I'd say is automation with simple failsafes. Something as simple as my automatic top up (tunze) which runs from a 5g pail. The pail will only fill twice a day. That way if the ATO fails and stays on, worst case scenario it dumps one or two 5g pails into the system before my wife notices something funny like the red light blinking on the tunze controller or the sound of the pump just whirring away in an empty pail. If I had it tied into a large RO reservoir it could be catastrophic. My dosing being run through the GHL Dosers is very slick as well. I just make sure my 5L reservoirs are full before heading out and they will last for two weeks.
I like to be able to look at my parameters on my phone at work through the GHL Profilux. Plus it gives me alarms for if there is water on the floor below the tank and sumps, also if there seems to be a flow issue, raising the water level in the sumps.
And in the end I have an emergency drain that means if the system over fills for some reason it goes down a drain, not on my floor. It really comes down to buying high end equipment, keeping your equipment in decent working order, and trusting those you leave in charge. My wife doesn't test unless she notices something is weird and then I direct her on which test to do. She simple feeds the fish every evening and that's it.
Have a friend your tank sitter can call if SHTF, and be calm with her if something is going wrong
You know your system better than anyone, it can be tough to explain things in the heat of the moment if you're panicking and they are as well.
I'm sure there are plenty of other things I do but I can't really think of them all off the top of my head right now. Ring ideas off me and I will let you know what I do