Actually I would not use a hole saw on either cast or extruded; IMO the best way by far to "drill" large diameter holes in acrylic is to use a router; drill a small pilot hole and tape on a template of sorts; it can be anything with a hole in it the size you want, then flushtrim around the inside of the template. Perfect hole every time, and no heat build up which stresses acrylic and can make it craze when exposed to solvent for welding. It works especially well for tube; you just use a PVC fitting the size you want the hole to be, then sand down the edge of the fitting so that it matches the inside curve of the tube. You can easily do this by taping some sandpaper inside the tube, then running the PVC fitting over it until it matches. I've used this method for dozens of drain holes in collection cups. I don't drill holes in large tube other than this, as I feel like it compromises the strength, presents a likely leak/structural failure point, and there are other ways of getting the plumbing in the tube. But, maybe I'm a little weird that way.
Deltec using extruded? Wow...if it's true, which I kind of doubt, it makes their prices even more rediculous, if that's possible. As for euroreef, I believe their extruded skimmers are much less expensive than their cast; probably they saw the writing on the wall and had to offer a cheaper alternative before too many other companies did.
I use only cast for the stuff I've made, but for DIY I certainly understand people using extruded. For a large company with a reputation to build and uphold over years of use, that's a different story.