Ok, this is helpful.
So if there's no way around avoiding "outside" air from replacing the warm humid air that's being exhausted from the fish room creating negative pressure in the home, it is important , however, which outside air it is. Is it then better to have an inlet to ensure it's fresh air, as opposed to air coming in from the walls, garage and attic that could be harmful, as tkeracer619 points out?
The dilemma for someone like me who lives in Houston is that the "fresh" air coming in from the outside will be hot and humid air most of the year, essentially defeating the purpose of exhausting warm and humid air in the first place... wouldn't it be better then to install a dehumidifier like James proposed? Or just monitor the home humidity and see whether the existing A/C can handle it?