When people talk about "reef safe", I think there's a misunderstanding that if something comes as part of a cleanup crew, they just dutifully go about sucking up detritus and inanimate things from the substrate. In the real reef, there is constant competition, and things are always eating other things. In reality, the animals we keep are usually in a precarious balance most of the time. Hermit crabs usually live by scavenging, but they are opportunistic feeders that will take advantage of a situation when they see it. Sometimes this means picking on another invert it sees as weaker or a coral that's not doing so well. I have seen a lot of hermits get quite nasty, they will pull other hermits or snails out of their shells if they can and feed on them, and sometimes take the shells for their own. Do a search for "hermit problems" here and you'll read about aggressive hermits all the time. Some species and individuals are better than others. I have a couple small red legged & some blue legged hermits that usually coexist somewhat peacefully, but sometimes I do find a dead body with legs that is half eaten in the tank, and yesterday, caught one of the larger ones tearing apart the tube of one of my tube worms. To me, it's still worth it to see the little buggers foraging around, so I keep most of them but banish them to the sump when they reach a certain size.