I worked at Sister's Hospital (Nurse's aide in the ICU) when I was in undergrad. I had a great experience. I've also spent time on the OB/GYN floor, so have had many chances to interact with the nurses in the NICU. The nurses in the NICU are amazing.
My Mom has worked as a nurse there for over 30 years, in both L&D and the operating room. She loves where she works.
I think Buffalo is a pretty awesome place. The city is of decent size (bigger than Syracuse). People are really friendly. I grew up in the suburbs, but went to school in the city (at Canisius, which is right down the street from Sister's Hospital), and I felt safe almost everywhere I went. There's a lot of things to do and places to eat as well. It's really easy to get around.