The only way to tell when a membrane needs replaced is to measure the TDS going in and the TDS coming out and determine the rejection rate. 75gpd and lower membranes should have a 96%+ rejection rate. If it is lower than that then it is probably time to replace the membrane. 100gpd membranes should have a 90%+ rejection rate.
One suggestion, allow it to run for several minutes to remove all the elevated TDS that happens when you first start it up. My membrane will read around 100TDS when first started but after a couple cups of water the TDS is around 18, that is with around 400TDS going in.