The larger the sump the more overflow you can handle from the main or auxiliary tanks in case a return pump fails or the power is cut. It also gives you room to add more reactors and pumps in future should the need arise. Some people use the extra room in a large sump for an algal refugium, an algal turf scrubber, a cryptic refugium or a deep sand bed filter.
Once you have the room the only limitation is your imagination.
Dave.M