Prazipro not killing flukes

[Newsmyrna80]

I have had a Flame Angel in a QT since March 13th. He has flukes which has been confirmed via FW dips. I have been treating with Prazipro to not avail. I wrote to Hikari and they suggested the following regimen: 50% water change dose with Prazipro, 3 days later do water change, dose again, 3 days later do water change dose again, 3 days later water change dose again. The Flame was scratching today so I dipped him...flukes:mad2:
Does anyone have experience with Quick Cure as a bath? Will it kill the eggs? Thank you!!!

 

[snake42490]

Have you checked the expiration date on your prazipro? I have had great luck with the product working to cure flukes. I double checked my tank volume and dosed exactly as instructed. If the medicine is old or has been opened for a while it could have gone bad. How many flukes are coming out in the freshwater dip?

Sometimes I have had to do a second dose of prazipro, they say to do it a few days apart because the medicine doesn't kill the eggs. I also believe the product is only active for three days in the water.

 

[HumbleFish]

I prophylactically treat with Prazipro twice, 5 days apart. That regimen seems to get the flukes and the "next generation" from any eggs left behind. Some advocate using Metronidazole to eradicate stubborn flukes and nationalfishpharm sells "De-Los" for flukes. But I don't have experience using either (for flukes). Metro I don't like because of the nasty side effects.

 

[Newsmyrna80]

Have you checked the expiration date on your prazipro? I have had great luck with the product working to cure flukes. I double checked my tank volume and dosed exactly as instructed. If the medicine is old or has been opened for a while it could have gone bad. How many flukes are coming out in the freshwater dip?

Sometimes I have had to do a second dose of prazipro, they say to do it a few days apart because the medicine doesn't kill the eggs. I also believe the product is only active for three days in the water.

Wow! Thanks for the quick response The only numbers I see stamped on he bottle are "05261003". I don't see any dates. I could identify 4 flukes and a stringlike substance (a worm?).

I dosed every 3 days for 2 weeks.

 

[Newsmyrna80]

I prophylactically treat with Prazipro twice, 5 days apart. That regimen seems to get the flukes and the "next generation" from any eggs left behind. Some advocate using Metronidazole to eradicate stubborn flukes and nationalfishpharm sells "De-Los" for flukes. But I don't have experience using either (for flukes). Metro I don't like because of the nasty side effects.

I was looking at De-Los but I've read that it can be harsh on fish. I have no experience with Metro either.

 

[HumbleFish]

I was looking at De-Los but I've read that it can be harsh on fish.

I've heard the same thing. But supposedly it kills the flukes & eggs, so one and done.

 

[Newsmyrna80]

I've heard the same thing. But supposedly it kills the flukes & eggs, so one and done.

Well, that is something to consider. I have a feeling this Prazipro I have is old. I just looked it up online and the bottle online is completely different and more expensive than what I paid at my LFS.

 

[coral_lagoon]

Is it possible we're witnessing a new strain of flukes resistant to Prazipro..

 

[Newsmyrna80]

Is it possible we're witnessing a new strain of flukes resistant to Prazipro..

That's what I'm wondering:uhoh3:

 

[ironwill723]

Careful with the Quick Cure. Strong stuff especially with angelfish. I'd be hesitant to use on that fish.

 

[Newsmyrna80]

Careful with the Quick Cure. Strong stuff especially with angelfish. I'd be hesitant to use on that fish.

That's good to know. I just heard back from Hikari and it appears the bottle I have has apparently gone through a freeze.They said it is supposed to have a faint pink tint to it. Mine is clear to a faint yellow tint. This may be why the flukes keep coming back. :headwally:

 

[alprazo]

First, I believe that De-los is an organophosphate like Dylox or Trichlorfon. The stuff works for most external flukes, amphipods, copepods, isopods, worms etc.. , but is brutal. I have had fish immediatly turn rigid, go belly up and die within seconds from the stuff, while it has surely saved others when all else failed. Here is what the label reads - BTW - Sarin and VX gases are in the organophosphate family.

Personal Protection Equipment: All personal protection equipment on the parent label shall apply. In addition, handlers who are mixing, loading, or applying Dylox® 80 must wear a double layer of clothing, long pants, gloves, shoes, socks, safety glasses or goggles, and a respirator. Remove contaminated clothing and wash before reuse.

As for prazi-pro. I no longer use it and instead 100% pure praziquantil powder. When I would though I found out that 1.5-2x the dose for a short period would often help. Dips work great for new fish - 20mg/l for adult fish at 1.5 hr bath or 10mg/l for 3 hours for juveniles.

Prazi is not effective in all monogenia. I have had to use febendazole and even Dylox on certain flukes in the past. There are reports of febendazole causing liver toxicity in fish so I wouldn't use it first line. Stick with Prazi. PM me is you can't clear the Flukes. Formalin works too.

 

[Newsmyrna80]

First, I believe that De-los is an organophosphate like Dylox or Trichlorfon. The stuff works for most external flukes, amphipods, copepods, isopods, worms etc.. , but is brutal. I have had fish immediatly turn rigid, go belly up and die within seconds from the stuff, while it has surely saved others when all else failed. Here is what the label reads - BTW - Sarin and VX gases are in the organophosphate family.

Personal Protection Equipment: All personal protection equipment on the parent label shall apply. In addition, handlers who are mixing, loading, or applying Dylox® 80 must wear a double layer of clothing, long pants, gloves, shoes, socks, safety glasses or goggles, and a respirator. Remove contaminated clothing and wash before reuse.

Ok, nuff said, will NOT be using this stuff. Geesh, even after all the warning signs DeLos is not effective against all flukes.

As for prazi-pro. I no longer use it and instead 100% pure praziquantil powder. When I would though I found out that 1.5-2x the dose for a short period would often help. Dips work great for new fish - 20mg/l for adult fish at 1.5 hr bath or 10mg/l for 3 hours for juveniles.

I understand the Prazipro will not kill eggs so I am assuming the powder will not as well? I have a Flame Angel in a QT. He's been there 5 weeks. If I could find something that will kills the eggs as well as the adults, and not harm the fish, I would set up a new QT, dip the fish and put into the new QT.

Prazi is not effective in all monogenia. I have had to use febendazole and even Dylox on certain flukes in the past. There are reports of febendazole causing liver toxicity in fish so I wouldn't use it first line. Stick with Prazi. PM me is you can't clear the Flukes. Formalin works too.

I ordered a microscope to see exactly what kind of Trematoda I'm dealing with. Apparently the Prazipro I got from my LFS had gone through a freeze so maybe that is why it is not working. I've ordered some online so hopefully that will do the trick. I do have Formalin and Malachite Green which I've used before as a dip. Do you have a brand of Formalin you recommend?

Thank you to all for the great responses! A lot of my questions have been answered:spin1:

 

[triggreef]

Just wondering during your dosing did the fish lose appetite? Because I know when I did it they certainly did for a few days for sure. If they didn't lose appetite then I'd say it was either too low of a dose or bad medicine.

 

[Dmorty217]

First, I believe that De-los is an organophosphate like Dylox or Trichlorfon. The stuff works for most external flukes, amphipods, copepods, isopods, worms etc.. , but is brutal. I have had fish immediatly turn rigid, go belly up and die within seconds from the stuff, while it has surely saved others when all else failed. Here is what the label reads - BTW - Sarin and VX gases are in the organophosphate family.

Personal Protection Equipment: All personal protection equipment on the parent label shall apply. In addition, handlers who are mixing, loading, or applying Dylox® 80 must wear a double layer of clothing, long pants, gloves, shoes, socks, safety glasses or goggles, and a respirator. Remove contaminated clothing and wash before reuse.

As for prazi-pro. I no longer use it and instead 100% pure praziquantil powder. When I would though I found out that 1.5-2x the dose for a short period would often help. Dips work great for new fish - 20mg/l for adult fish at 1.5 hr bath or 10mg/l for 3 hours for juveniles.

Prazi is not effective in all monogenia. I have had to use febendazole and even Dylox on certain flukes in the past. There are reports of febendazole causing liver toxicity in fish so I wouldn't use it first line. Stick with Prazi. PM me is you can't clear the Flukes. Formalin works too.

Dylox is a powder used in lawn care to kill insects, I NEVER could imagine putting this in my tank!

 

[Newsmyrna80]

Just wondering during your dosing did the fish lose appetite? Because I know when I did it they certainly did for a few days for sure. If they didn't lose appetite then I'd say it was either too low of a dose or bad medicine.

The first time I dosed they did. Since then they have been eating fine. I do have an air stone in the QT since Prazipro reduces the oxygen.

 

[Newsmyrna80]

I talked to the lab tech at Hikari who mixes Prazipro. I explained the problem with the Prazipro not killing the flukes and he seems to think that I am dealing with 2 different kind of species. He gave the following dosing instructions:
Do a 20% water change. Add 1 1/2 teaspoon Prazipro for every 10 gallons. He said to gradually add it and watch the fish. Wait 5 days do a 20% water change. Dose 1 1/2 teaspoon Prazipro. Wait 5 days do a water change and observe fish.
He said this amount is still safe for the fish.

 

[coral_lagoon]

I talked to the lab tech at Hikari who mixes Prazipro. I explained the problem with the Prazipro not killing the flukes and he seems to think that I am dealing with 2 different kind of species. He gave the following dosing instructions:
Do a 20% water change. Add 1 1/2 teaspoon Prazipro for every 10 gallons. He said to gradually add it and watch the fish. Wait 5 days do a 20% water change. Dose 1 1/2 teaspoon Prazipro. Wait 5 days do a water change and observe fish.
He said this amount is still safe for the fish.

This is true. I found out first hand when my assistant dosed over 4 tablespoons of Prazipro in my 125 gallon. To my amazement none of the fish died. They did react to the overdose, like pooping, regurgitating the foods in their stomachs,but this is like quadruple the overdose scenario. After 3 days they were back to normal. Eating and looking good. The flukes, they were nuked..

 

[Newsmyrna80]

This is true. I found out first hand when my assistant dosed over 4 tablespoons of Prazipro in my 125 gallon. To my amazement none of the fish died. They did react to the overdose, like pooping, regurgitating the foods in their stomachs,but this is like quadruple the overdose scenario. After 3 days they were back to normal. Eating and looking good. The flukes, they were nuked..

"Flukes nuked" music to my ears By any chance did you have any wrasses? I've read that they can be sensitive to overdosing.
Thank you, by the way, for your response....makes me feel MUCH better

 

[coral_lagoon]

"Flukes nuked" music to my ears By any chance did you have any wrasses? I've read that they can be sensitive to overdosing.
Thank you, by the way, for your response....makes me feel MUCH better

Hey no problem man. :beer:

I hear ya though. My fish were all pale looking,scratching before the Prazipro. As far as wrasses I didn't have any in that tank. I wouldn't know. I can tell you that my sebae pair clownfish reacted to the heavy overdose ( pooping) . Picasso trigger was the one that regurgitated it's food. It did not phase my Golden Hawkfish,and Passer Angel..