I'd place it on the opposite end of the overflow on the side wall. The back wall would stunt its performance because you would be missing out on the spread of it. Flow mode, height and left/right orientation are up to you. There is no correct setting for these pumps, that is why there are multiple modes. Just cycle through the modes and play with it until you get the flow you like, then open the manual and figure out what setting you are using :bounce3:.
I'd place the Koralia 4 on the opposite side wall blowing directly at your vortech. The others I would try my best to hit any dead spots in your rock work with.
To answer your question - I am using two MP40's anti-sync on long pulse mode.