<a href=showthread.php?s=&postid=12131812#post12131812 target=_blank>Originally posted</a> by greenbean36191
Yep, the simple version is that enzymes catalyze metabolic chemical reactions and as the temperature increases those reactions speed up just like most chemical reactions. As the temp keeps increasing you eventually get to a maximum temp, after which the catalytic enzyme starts to denature and lose functionality. At that point the rate drops off dramatically.
The real world is a lot more complicated than that though. You could literally write volumes on the subject and many people have spent their entire careers working out what exactly is going on. The short version of the long story is that there's a range of temperatures where you hover around the same maximum rate because there are multiple versions of the rate defining enzymes. In a hypothetical critter you would have one version of an enzyme that maxes out between 78-80, one between 80-83, and one between 81-85, all of which work at roughly the same maximum rate. As the temp increases from 78-85, which enzyme is carrying the bulk of the load changes, but since you're already near the max rate for all the forms you end up getting a plateau over that range rather than increasing much more. Beyond that range, repair mechanisms take over and you get a slight increase before things start going back downhill fast.
The different isoforms of the enzymes also play into the acclimatization issue because the relative proportions of the different forms in the enzyme pool change over time. If it's always 78, then the animal stops wasting resources making the other forms that it doesn't need and devotes almost everything to the 78 degree form. That ends up being a gamble though because as long as everything stays the same that works out great, but if things change you don't have a very large pool of the enzymes you need and things get bad in a hurry.