On the first page of my build thread is this picture:
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Looking beyond the sump you will see a vertical white board. When I built my stand, this board was under the back corner of the 75g tank. While the system was running I realized that the evaporation would drain the 5g ATO bucket in less than a week during certain parts of the year. While trying to find a bigger ATO container, on more than one occasion this leg (and its mirror on the other side) caused me to abandon one container option after another. If I had made the front so it supported the 75g and built the back support large enough to support either a 48" or 72" tank, configuring items under the stand would be infinitely easier.
Going 2X6 doesn't hurt especially if you are going with a 48" opening. It all depends on the final design.
Don't forget to post pics of the final build.
As promised a while back, here the final frame for my hybrid stand for 120G/180G. Front door opening is 46" 3/4. I minimized the interior footprint of the uprights for the 120G (48"). Bottom will be a pond liner, simple and no loss of space. I stained it because I don't like the look of 2*4 and sealed with 3 coat of spar urethane. I'm not sure yet on the skin and I'm running out of time as it's getting cold up here in Canada. I don't have a garage yet...

