Dipan,
I am setting up a large system right now that has the drains going down under the house and back up into the filter room. I dont have the luxury of using 3 drains, but I used 2" for the main siphon drain and 2.5" for the emg / open channel drain.
They will still work, but due to the length and head pressure of going back up, you will need to oversize your plumbing, or reduce your flowrates accordingly.
Also, upon pump startup, there will be reistance to flow until the water starts moving through the pipes then stabilizes. You will need to figure this into your end flowrate. You do not want the tank to overflow before getting a good siphon running. I use a high tank level sensor (Profilux contoller on this one) to shut the return pump off before this ever occurs. You'll need to adjust your return pump valve after setting it all up.
Also, you will periodically want to close the siphon drain valve and flush out any sediment that builds up in the open channel drain line. Since flow is so low it will become a major sediment trap.
HTH,
Chris
PS Jim, you are CAD MACHINE!