I think the water volume moving trough the skimmer and the amount of bubble surface area matter a lot in terms of total export and gas exchange.
24/7 is my preference with two ASM 4xx skimmers on a 650 gallon system . Each has a needle wheel wheel ,which produces copious fine bubbles via a sedra 15000 pump rated at 1500gph per hour ,for a total water movement of 3000 gph , which turns over the 650 water volume nearly 5xs per hour. Each is rated for up to 500gallon systems.
There is still always plenty of plankton in the water . Much of it has life cycles with phases that are benthic.
IMO turning of the skimmer pump for significant periods of time with stagnant water in the skimmer column is an unnecessary risk. Not much if any plankton is going to propagate in 6 hours anyway. The loss of aeration for significant periods of time will also cause a lack of constancy in gas exchange and potentially lead to hypoxic conditions in areas of the tank.
If I were inclined to stop skimming for a period of time, I'd just close off the air flow ,stopping the bubble formation, and let the water pump keep going. Even then the loss of aeration is a concern.